In the present research work, an attempt was made to improve the solubility and dissolution rate of a poorly soluble drug, Risperidone by solid dispersion method using mannitol(1:1), Urea(1:1), PEG4000(1:1), PEG6000(1:2), PVPK30(1:4) as a carrier with varying drug: carrier ratios. Evaluation of solid dispersion i.e. in vitro- dissolution, differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), X-ray diffraction (XRD) was performed. The solid dispersion of PEG 4000(1:1) showed the best cumulative drug release. The solid dispersions were then formulated as fast dissolving tablets by using 22factorial design and were subjected to various preformulation and post formulations studies. The evaluation of tablet batches i.e. wetting time, disintegrating time, hardness, friability, drug content, in vitro release, and stability parameters have been studied. After the evaluation of all four batches, the F2 batch shows the best cumulative release (99.58%) and also disintegration time (14 sec). From this study, it can be concluded that dissolution rate of risperidone could be enhanced by tablets containing solid dispersion by direct compression technique.
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